The Journal of Experimental Medicine
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Published online
doi:10.1084/jem.20091683
The Journal of Experimental Medicine, Vol. 206, No. 9, 1839-1843
The Rockefeller University Press, 0022-1007 $30.00
© Casanova et al.
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COMMENTARY

 Revisiting Crohn's disease as a primary immunodeficiency of macrophages

Jean-Laurent Casanova and Laurent Abel

J.-L. Casanova and L. Abel are at Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York 11065 and Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Recherche et de la Santé Médicale, University Paris Descartes, U.550, Paris, France

CORRESPONDENCE J.-L.C.: casanova{at}rockefeller.edu


ABSTRACT
Despite two decades of mouse immunology and human genetics studies, the pathogenesis of Crohn's disease (CD) remains elusive. New clinical investigations suggest that CD may be caused by inborn errors of macrophages. These errors may result in impaired attraction of granulocytes to the gut wall, causing impaired clearance of intruding bacteria, thereby precipitating the formation of granulomas. This theory paves the way for a macrophage-based Mendelian genetic dissection of CD.

© 2009 Casanova and Abel
This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


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