JEM -- Table of Contents (206 [9])

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Aug 31 2009; 206 (9)

       IN THIS ISSUE

       PEOPLE & IDEAS

       COMMENTARIES

       BRIEF DEFINITIVE REPORTS

       ARTICLES

       FROM THE JCB

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PODCAST:

August 24, 2009 Regulated Ire1-dependent decay of mRNAs; Reduced immune surveillance in aging skin ; Sch9 promotes age-dependent mutations in yeast

IN THIS ISSUE:

IN THIS ISSUE [PDF]

Age-induced T cell troubles [Full Text]

Interferin' with shock [Full Text]

Giving gut DCs personality [Full Text]

DC-T reg cell checks and balances [Full Text]

Strep's key to the brain [Full Text]

PEOPLE & IDEAS:

Ajit Varki: On the origin of maladies

Amy Maxmen
J. Exp. Med. 2009 206: 1836-1837. Published online Aug 31 2009, 10.1084/jem.2069pi. [Full Text] [PDF (714K)]

COMMENTARIES:

Revisiting Crohn's disease as a primary immunodeficiency of macrophages

Jean-Laurent Casanova and Laurent Abel
J. Exp. Med. 2009 206: 1839-1843. Published online Aug 17 2009, 10.1084/jem.20091683. [Abstract] [Full Text] [PDF (1597K)]

BRIEF DEFINITIVE REPORTS:

The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion

Satoshi Uchiyama, Aaron F. Carlin, Arya Khosravi, Shannon Weiman, Anirban Banerjee, Darin Quach, George Hightower, Tim J. Mitchell, Kelly S. Doran, and Victor Nizet
J. Exp. Med. 2009 206: 1845-1852. Published online Aug 17 2009, 10.1084/jem.20090386. [Abstract] [Full Text] [PDF (2329K)] [PDF+supp data (2799K)] [Supplemental Material]

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo

Guillaume Darrasse-Jèze, Stephanie Deroubaix, Hugo Mouquet, Gabriel D. Victora, Thomas Eisenreich, Kai-hui Yao, Revati F. Masilamani, Michael L. Dustin, Alexander Rudensky, Kang Liu, and Michel C. Nussenzweig
J. Exp. Med. 2009 206: 1853-1862. Published online Aug 10 2009, 10.1084/jem.20090746. [Abstract] [Full Text] [PDF (3550K)] [PDF+supp data (6203K)] [Supplemental Material]

TPL-2 negatively regulates interferon-β production in macrophages and myeloid dendritic cells

Frank Kaiser, Dorthe Cook, Stamatia Papoutsopoulou, Ricardo Rajsbaum, Xuemei Wu, Huei-Ting Yang, Susan Grant, Paola Ricciardi-Castagnoli, Philip N. Tsichlis, Steven C. Ley, and Anne O'Garra
J. Exp. Med. 2009 206: 1863-1871. Published online Aug 10 2009, 10.1084/jem.20091059. [Abstract] [Full Text] [PDF (2308K)] [PDF+supp data (2744K)] [Supplemental Material]

Type I interferon drives tumor necrosis factor–induced lethal shock

Liesbeth Huys, Filip Van Hauwermeiren, Lien Dejager, Eline Dejonckheere, Stefan Lienenklaus, Siegfried Weiss, Georges Leclercq, and Claude Libert
J. Exp. Med. 2009 206: 1873-1882. Published online Aug 17 2009, 10.1084/jem.20090213. [Abstract] [Full Text] [PDF (7685K)]

ARTICLES:

Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease

Andrew M. Smith, Farooq Z. Rahman, Bu'Hussain Hayee, Simon J. Graham, Daniel J.B. Marks, Gavin W. Sewell, Christine D. Palmer, Jonathan Wilde, Brian M.J. Foxwell, Israel S. Gloger, Trevor Sweeting, Mark Marsh, Ann P. Walker, Stuart L. Bloom, and Anthony W. Segal
J. Exp. Med. 2009 206: 1883-1897. Published online Aug 3 2009, 10.1084/jem.20091233. [Abstract] [Full Text] [PDF (6341K)] [PDF+supp data (11940K)] [Supplemental Material]

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

Sarah M. McWhirter, Roman Barbalat, Kathryn M. Monroe, Mary F. Fontana, Mamoru Hyodo, Nathalie T. Joncker, Ken J. Ishii, Shizuo Akira, Marco Colonna, Zhijian J. Chen, Katherine A. Fitzgerald, Yoshihiro Hayakawa, and Russell E. Vance
J. Exp. Med. 2009 206: 1899-1911. Published online Aug 3 2009, 10.1084/jem.20082874. [Abstract] [Full Text] [PDF (2097K)] [PDF+supp data (2935K)] [Supplemental Material]

Cancer cell–derived microparticles bearing P-selectin glycoprotein ligand 1 accelerate thrombus formation in vivo

Grace M. Thomas, Laurence Panicot-Dubois, Romaric Lacroix, Françoise Dignat-George, Dominique Lombardo, and Christophe Dubois
J. Exp. Med. 2009 206: 1913-1927. Published online Aug 10 2009, 10.1084/jem.20082297. [Abstract] [Full Text] [PDF (5773K)] [PDF+supp data (6555K)] [Supplemental Material]

Decreased TNF- ${alpha}$ synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4⁺ T cells during aging

Elaine Agius, Katie E. Lacy, Milica Vukmanovic-Stejic, Ann L. Jagger, Anna-Pia Papageorgiou, Sue Hall, John R. Reed, S. John Curnow, Judilyn Fuentes-Duculan, Christopher D. Buckley, Mike Salmon, Leonie S. Taams, James Krueger, John Greenwood, Nigel Klein, Malcolm H.A. Rustin, and Arne N. Akbar
J. Exp. Med. 2009 206: 1929-1940. Published online Aug 10 2009, 10.1084/jem.20090896. [Abstract] [Full Text] [PDF (4404K)] [PDF+supp data (5462K)] [Supplemental Material][Related biobytes podcast]

Displaying Fel d1 on virus-like particles prevents reactogenicity despite greatly enhanced immunogenicity: a novel therapy for cat allergy

Nicole Schmitz, Klaus Dietmeier, Monika Bauer, Melanie Maudrich, Stefan Utzinger, Simone Muntwiler, Philippe Saudan, and Martin F. Bachmann
J. Exp. Med. 2009 206: 1941-1955. Published online Aug 10 2009, 10.1084/jem.20090199. [Abstract] [Full Text] [PDF (3172K)] [PDF+supp data (3893K)] [Supplemental Material]

Dissection of PIM serine/threonine kinases in FLT3-ITD–induced leukemogenesis reveals PIM1 as regulator of CXCL12–CXCR4-mediated homing and migration

Rebekka Grundler, Laurent Brault, Christelle Gasser, Alex N. Bullock, Tobias Dechow, Sabine Woetzel, Vanda Pogacic, Antonello Villa, Sabine Ehret, Georgina Berridge, Anke Spoo, Christine Dierks, Andrea Biondi, Stefan Knapp, Justus Duyster, and Juerg Schwaller
J. Exp. Med. 2009 206: 1957-1970. Published online Aug 17 2009, 10.1084/jem.20082074. [Abstract] [Full Text] [PDF (5488K)] [PDF+supp data (11052K)] [Supplemental Material]

Augmented TLR9-induced Btk activation in PIR-B–deficient B-1 cells provokes excessive autoantibody production and autoimmunity

Tomohiro Kubo, Yuki Uchida, Yuko Watanabe, Masahiro Abe, Akira Nakamura, Masao Ono, Shizuo Akira, and Toshiyuki Takai
J. Exp. Med. 2009 206: 1971-1982. Published online Aug 17 2009, 10.1084/jem.20082392. [Abstract] [Full Text] [PDF (5167K)] [PDF+supp data (9875K)] [Supplemental Material]

Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8

Dipyaman Ganguly, Georgios Chamilos, Roberto Lande, Josh Gregorio, Stephan Meller, Valeria Facchinetti, Bernhard Homey, Franck J. Barrat, Tomasz Zal, and Michel Gilliet
J. Exp. Med. 2009 206: 1983-1994. Published online Aug 24 2009, 10.1084/jem.20090480. [Abstract] [Full Text] [PDF (4111K)] [PDF+supp data (5826K)] [Supplemental Material]

A role for CD47 in the development of experimental colitis mediated by SIRP ${alpha}$ ⁺CD103^– dendritic cells

Genevieve Fortin, Marianne Raymond, Vu Quang Van, Manuel Rubio, Patrick Gautier, Marika Sarfati, and Denis Franchimont
J. Exp. Med. 2009 206: 1995-2011. Published online Aug 24 2009, 10.1084/jem.20082805. [Abstract] [Full Text] [PDF (7873K)] [PDF+supp data (10782K)] [Supplemental Material]

Distinction of the memory B cell response to cognate antigen versus bystander inflammatory signals

Micah J. Benson, Raul Elgueta, William Schpero, Michael Molloy, Weijun Zhang, Edward Usherwood, and Randolph J. Noelle
J. Exp. Med. 2009 206: 2013-2025. Published online Aug 24 2009, 10.1084/jem.20090667. [Abstract] [Full Text] [PDF (3974K)] [PDF+supp data (9270K)] [Supplemental Material]

Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses

Akihiro Kimura, Tetsuji Naka, Taisuke Nakahama, Ichino Chinen, Kazuya Masuda, Keiko Nohara, Yoshiaki Fujii-Kuriyama, and Tadamitsu Kishimoto
J. Exp. Med. 2009 206: 2027-2035. Published online Aug 24 2009, 10.1084/jem.20090560. [Abstract] [Full Text] [PDF (2585K)] [PDF+supp data (3513K)] [Supplemental Material]

Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

Matthew J. Robinson, Fabiola Osorio, Marcela Rosas, Rui P. Freitas, Edina Schweighoffer, Olaf Groß, J. Sjef Verbeek, Jürgen Ruland, Victor Tybulewicz, Gordon D. Brown, Luis Ferreira Moita, Philip R. Taylor, and Caetano Reis e Sousa
J. Exp. Med. 2009 206: 2037-2051. Published online Aug 24 2009, 10.1084/jem.20082818. [Abstract] [Full Text] [PDF (5344K)] [PDF+supp data (8616K)] [Supplemental Material]

FROM THE JCB:

Real-time in vivo imaging of p16^Ink4a reveals cross talk with p53

Kimi Yamakoshi, Akiko Takahashi, Fumiko Hirota, Rika Nakayama, Naozumi Ishimaru, Yoshiaki Kubo, David J. Mann, Masako Ohmura, Atsushi Hirao, Hideyuki Saya, Seiji Arase, Yoshio Hayashi, Kazuki Nakao, Mitsuru Matsumoto, Naoko Ohtani, and Eiji Hara [Full Text]

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins

Delphine Mérino, Maybelline Giam, Peter D. Hughes, Owen M. Siggs, Klaus Heger, Lorraine A. O'Reilly, Jerry M. Adams, Andreas Strasser, Erinna F. Lee, Walter D. Fairlie, and Philippe Bouillet [Full Text]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.